Thomas R. O'Donnell

Posts Tagged ‘University of Maryland’

The ramifications of using pigs for people parts

In Uncategorized, University research on April 5, 2022 at 12:22 pm
University of Maryland surgeons prepare a pig heart for transplant into a 57-year-old man. Credit: University of Maryland.
University of Maryland Medical Center surgeons prepare a pig heart for transplant into a 57-year-old man. Credit: University of Maryland.

Xenotransplantation – replacing human organs with ones from animals – has advanced since I reported last fall that the first pig kidney attached to a living human came from Iowa.

Doctors repeated the experiment at least twice, once at the University of Alabama at Birmingham on September 30, 2021 and again at New York University, which conducted the first kidney xenotransplant.

Then, in early January, University of Maryland Medical Center surgeons replaced a 57-year-old man’s failing heart with one from a genetically engineered pig. He has since died.

All the organs came from Revivicor, a division of medical conglomerate United Therapeutics. The first kidney transplanted at NYU came from a pig raised at an Iowa facility operated by Exemplar Genetics, a subsidiary of Sioux Center’s Trans Ova Genetics.

The pigs are engineered to remove three genes that would prompt a human body to reject the transplanted organ. Six human genes that Revivicor inserted into swine DNA are designed to help human bodies accept a transplanted organ.

The genetically modified pigs must be raised in medically conditions avoid exposing them to diseases hogs share with humans. Trans Ova subsidiary Exemplar specializes in providing such settings for research animals.

Although the first NYU kidney came from Iowa, it appears the other pig organs may have come from elsewhere. The Alabama pig was raised at the university. The New Yorker magazine notes that the heart transplanted in Maryland came from a Virginia facility.

Iowa may not have a monopoly on genetically modified hogs for transplant purposes, but the question remain: Is it ethical to turn animals into spare parts stores for humans?

Read the rest of this entry »

Cold facts: UNI-led effort probes Arctic sustainability

In University research on March 10, 2014 at 10:07 am

UNI Geography Professor Andrey Petrov, in furry hat and gloves, holds a piece of Lake Baikal ice in front of his face  during his most recent Siberian visit.

UNI Professor Andrey Petrov hold a piece of Lake Baikal during his recent Siberian visit. Credit: Andrey Petrov.

When I contacted Andrey Petrov a week ago, he was returning from the Irkutsk region of Siberia.

The University of Northern Iowa geography professor makes frequent visits to Siberia and other similarly remote – and cold – regions, including Canada’s Yukon Territory and northern Russia. This time he was interviewing residents of villages and towns near Lake Baikal about the region’s reindustrialization. In the last century the area had seen an inflow of industry that went bust. Now it’s rising again, thanks to the search for oil.

“Unfortunately, it’s warmer there than here,” Petrov said from Cedar Falls on Monday, when the thermometer was scraping to get above zero Fahrenheit. “It was pretty sunny there and it was probably 20s. … For them it’s warmer than usual.”

The extreme conditions and isolation are some of the reasons Petrov, a native Russian, returns to places like Irkutsk and Yellowknife. “I’m fascinated with the resilience of people living in difficult conditions,” he says, but the challenges facing Arctic communities go beyond the weather and distance.

Those challenges are the subject of a new project Petrov directs. Headquartered at UNI, the five-year program, supported with nearly $750,000 of National Science Foundation money, will knit researchers from multiple institutions around the globe’s northern regions. Their goal: understanding Arctic communities and how they can enhance their development, health and well being while preserving societies and ecosystems.

It’s a big job. Five years won’t be enough, Petrov says. Read the rest of this entry »

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